Etomidate infusion
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of etomidate associated with prolonged i.v. infusion.
Plasma concentrations of etomidate have been measured in six patients who required intermittent positive pressure ventilation following surgery. There was an approximately linear relationship between the plasma concentration and the rate of infusion of etomidate. The drug exhibited linear pharmacokinetics over a 10-fold variation in plasma concentration. The decrease in the plasma concentration...
متن کاملMinimum infusion rate and adrenocortical function after continuous infusion of the novel etomidate analog ET-26-HCl in rats
BACKGROUND Because etomidate induces prolonged adrenal suppression, even following a single bolus, its use as an infused anesthetic is limited. Our previous study indicated that a single administration of the novel etomidate analog methoxyethyletomidate hydrochloride (ET-26-HCl) shows little suppression of adrenocortical function. The aims of the present study were to (1) determine the minimum ...
متن کاملAdrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate
INTRODUCTION Etomidate is no longer administered as a continuous infusion for anesthetic maintenance or sedation, because it results in profound and persistent suppression of adrenocortical steroid synthesis with potentially lethal consequences in critically ill patients. We hypothesized that rapidly metabolized soft analogues of etomidate could be developed that do not produce persistent adren...
متن کاملEffects of continuous infusion of etomidate at various dose rates on adrenal function in dogs
BACKGROUND Etomidate is a commonly used sedative in intravenous anesthesia. The aim of this study was to compare the effects of various etomidate doses administered by continuous infusion on adrenal function in dogs under general anesthesia. METHODS Thirty-six healthy adult male dogs were randomly divided into six groups. Sodium pentobarbital alone was administered to the control group (group...
متن کاملEtomidate as an antiarrhythmic.
Editor—We wish to report a case of etomidate reverting ventricular tachycardia to sinus rhythm. Although there have been several case reports and studies demonstrating the antiarrhythmic affects of propofol this has not been true of etomidate. A 59-yr-old man presented to the emergency department with a 2 h history of central chest pain radiating to the left arm and palpitations. He denied any ...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1983
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.1983.tb15182.x